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Most differentially expressed pathways (DEPs) showed opposite directions of regulation (Figure 6B).
We did not find any clearer clustering of promoters associated with gene regulation (Figure S5).
The total effect of ALT-PTK6 expression in cancer cells may be negative growth regulation (Figure 5B and C).
This transcriptomic analysis using tilling arrays for L. monocytogenes highlighted clusters of regulation (Figure 6 and Table S9).
As expected, this mutant protein accumulated quantitatively in the nucleus (Figure 7B) and was able to fully restore CbfA-CTD-dependent gene regulation (Figure 8).
Of these, 17 were altered at the transcript level by EBV, and many required one or more of the EBNA3s for this regulation (Figure 4).
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The Specific protein 3 gene (Sp3; 0.8-fold down-regulation; Figure 5A) encodes for transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes.
Expression of the UASitpr+ transgene with either Dilp2 or DdcGAL4 reduced this up-regulation (Figure 2H, I and J).
As expected, we found that co-incubation of recombinant Dkk1 protein with Wnt3A CM blocks Wnt3A-induced LRP6 down-regulation (Figure 5D).
This resulted in a balanced picture, i.e. no significant difference could be detected in the protein amount undergoing up and down-regulation (Figure 2B).
However, only spermine was able to up-regulate ligA for an extended period, up to 12 h p.i., while the other treatments exhibited down-regulation (Figure 1).
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