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More opaque associations may be trans-acting in a broader sense: the causative gene variant can be a molecular switch, and the metabolite it is associated with is in fact regulated indirectly by this molecular switch (further down in the regulation events).
Results in Fig. 10b and c clearly indicate that SUM149PT, SUM1315MO2 cancer cell lines have selective amplification and downregulation of genes regulating signal transduction, protein tyrosine kinases, cell proliferation, and cell cycle regulation events when compared to HMEC cells.
Recent studies have shown that epigenetic gene regulation events such as DNA methylation and histone modification play important roles in regulating NSC fate specification.
A complex network of molecular signals orchestrates the cellular changes and gene regulation events specific to each sex.
Other groups with time-specific up regulation events that occurred only at 24 h or at 12 h (groups D and H) were also observed.
Another category of regulation events consists of antisense RNA mechanisms.
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This suggests a wider regulatory antagonism of the two compounds in the early up-regulation events during differentiation.
Each module was also associated with a corresponding differentiation event matrix D recording the up-regulation events across the DGL compendium for that module.
From prior knowledge we expect that up- and down-regulation events should be approximately balanced.
We included self-loops within the network to account for auto-regulation events [ 40].
A BN being acyclic is not able to model feedbacks and self-regulation events.
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