EU regulations envisage off-label/unlicensed use only under limited 'special need' circumstances, including authorised clinical trials, compassionate/named patient use when no other treatment is available, emergency scenarios (e.g., pandemics) or at the discretion of a treating physician [ 32, 33, 35].
However, a relevant contribution to this regulation can be envisaged in the identified biological pathways related to the small GTPases RHO, RAC1, and CDC42 as they are known potential controllers of dynamic processes affecting the cytoskeleton such as the formation of stress fibers (RHO), lamellipodia (RAC1), and filopodia (CDC42) as well as membrane ruffling (RAC1).
Various permutations of models centred on Cbl-negative regulation can be envisaged.
Based on frequently observed changes to the DNA methylome in cancer, multiple putative effects on PRC-mediated gene regulation can be envisaged (Fig. 2).
Two levels of epigenetic gene regulation can now be envisaged: the classic form involving stable heritable changes and enhanced epigenetic modifications, which can be regarded as regulatory mechanisms orchestrating inducible responses at the cellular level which may or may not be heritable.
In the summer, FSA chief executive Tim Smith said the agency was now having to look at new sales outlets which did not exist when the 2006 regulations were drawn up: "We will also consider the impact of developments in the unpasteurised milk market, for example internet sales and vending machines which were not envisaged when the food hygiene regulations were introduced".
(2) Given that highly valuable applications will likely be envisaged with advances in research, regulations on the research purpose should be capable of responding flexibly to the advances in research.
We believe the industry is in a position to establish the sort of tough new system of independent, accountable press regulation with the power to investigate wrongdoing and levy fines, envisaged by the report.
Regulation of GIP secretion by the endocannabinoid system could be envisaged as part of the transition from a preprandial to a postprandial metabolic state.
Structural alloys applied to aerospace and power generation applications are expected to operate at temperatures exceeding those originally envisaged during their design to meet the tightening regulations on emissions and also to improve the efficiency of operation.
