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As listed in Table 2, we have divided the previous findings into three areas: correlation between protein connectivity and miRNA regulation complexity; miRNA-regulated specific proteins, the coordination role of miRNAs in regulating PPI networks; and identifying miRNA-regulated PPI networks in special diseases.
Recent research has investigated the regulatory rules between miRNAs and genes, and found, for example, that miRNAs preferentially regulate genes that have a high transcriptional regulation complexity [ 20] and that preferentially target downstream genes in cellular signaling flows [ 21].
In the Indonesian palm oil sector with regulation complexity, political sensitivity, and the participation of small-scale producers, such collaboration becomes an important strategy.
We further demonstrate that genes with increased number of alternative promoters are marked with features important to regulation complexity and disease origins, including increased gene length, duplicability and connectivity.
The described relationships between gene functions and regulation complexity can work in both directions.
It appears that we may need to more effectively address the challenges of evolved gene regulation complexity (Wray et al. 2003).
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The authors didn't cover how to address regulation complexities and overlaps.
Still, the many new discoveries are "revealing a level of regulation and complexity that I don't think the current organizational model of the genome ever envisioned," said Thomas R. Gingeras, professor and head of functional genomics at Cold Spring Harbor Laboratory.
Nevertheless, recent findings have suggested new layers of regulation and complexity.
The specific demands implied by such regulation add complexity to the management and administration practice in the health sector.
The challenge facing health tech is arguably much greater than other industries because it is working within the confines of tremendous regulation and complexity.
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