Sentence examples for regulation chip from inspiring English sources

Although interaction of CHIP with Hsp70/90 helps in recognizing new substrates and plays an important role in the client protein regulation, CHIP physically interacts with substrates through either its TPR or U-box domain.

We have also demonstrated the functional consequence of BACE1 regulation by CHIP on APP processing in both neurons and HEK-APP stable cells in which overexpression of CHIP reduced BACE1 activity through decreased β-cleavage product (CTFβ-99) and Aβ generation.

Clearly, regulation of CHIP at the mRNA level is an important strategy for regulating its biological activity.

An instance of posttranscriptional regulation of CHIP mRNA has been reported in the context of bone morphogenesis.

In agreement with differential regulation, our ChIP analysis revealed non-homogeneous PRC binding to the INK4b-ARF-INK4a locus.

Further support for a functional regulation of CHIP mediated ubiquitination was provided by Landrè and coworkers [ 116].

A limited number of studies have been devoted to understand the regulation of CHIP mRNA under different physiological and pathological contexts.

Menet JS, Rodriguez J, Rosbash M, 2012, Nascent-Seq Reveals Novel Features of Mouse Circadian Transcriptional Regulation [ChIP-seq], http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi acc=GSE36874, Publicly available at the NCBI Gene Expression Omnibus GSE3823 (Accession on: GSE36874).

These findings suggest that down-regulation of CHIP could cause overexpression of HER2 by preventing its degradation.

Bioinformatics focus on the developments of mathematical and computational tools to extract useful information from data produced by high-throughput biological techniques such as genome sequencing, protein sequences, gene regulation, gene networks, ChIP-on-chip and DNA microarrays data as well as mass spectrometry and MRI.

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