Further, we propose useful techniques including subsampling, regulation, and amplification for achieving overall computational efficiency.
HIV targets CD4+ T lymphocytes and hinders the regulation and amplification of immune cells (Douek et al. 2002).
Such engineered receptors can be used to activate a G protein pathway of interest rapidly and reversibly, mimicking the speed, localization, regulation, and amplification of endogenous GPCR signals.
Instead, RASSLs are activated by small-molecule drugs [6], allowing them to be used to activate specific G-protein pathways rapidly and reversibly and to mimic the speed, localization, regulation, and amplification of endogenous GPCR signals [7].
The lower expression of mitochondrial CK in extraocular muscles would diminish its proposed role for fine regulation and amplification of the energy state signal from the cytoplasm and control of mitochondrial oxidative phosphorylation [ 26, 34].
These subcellular structures can transfer bioactive molecules from parental to target cells, thus allowing for regulation and amplification of several biological mechanisms such as apoptosis or cell activation (inflammatory or autoimmune responses, cell proliferation or coagulation).
Similar response elements were found in the promoter regions of both the transcription factors and their target genes implying a possible parallel regulation or amplification of the environmental signals according to the metabolic/redox state in the cells.
Such lineage sequences contribute to the amplification, regulation and diversification of cell division in neocortex (Kriegstein et al., 2004; Pontious et al., 2008).
Paclitaxel sensitivity is predicted by up regulation of and amplification in the genes ANXA1, SSRP1, PAFAH1B2, and PSMG3: ANXA1 inhibits the activation of NF-kB by binding to p65 [ 31]; SSRP1 forms the chromatin transcription elongation factor FACT which is crucial to the anticancer mechanism of DNA damaging drugs [ 32]; and PSMG3 is a proteasome assembly chaperone [ 33].
Thus, mRNA up-regulation driven by this amplification does not seem to be related with mitosis regulation, spindle assembly, and chromatids segregation.
