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RNA protein interaction plays an important role in various cellular processes, such as protein synthesis, gene regulation, post-transcriptional gene regulation, alternative splicing, and infections by RNA viruses.
In this context, besides post-translational modifications of proteins, we have to consider feedback of metabolic flow and allosteric regulation, alternative protein structures, targeted proteolysis and/or redox regulation.
This step acts to initiate formation of the spliceosome onto the pre-mRNA and represents a stage in the reaction that is highly subject to regulation (alternative splicing).
To date, AS RNAs have been implicated in various aspects of eukaryotic gene expression as diverse as genomic imprinting, RNA interference, translational regulation, alternative splicing, or RNA editing [21], [22], [23].
Another layer of regulation, alternative splicing, leads to variances in the protein sequences themselves.
Trends in transcriptional regulation (alternative promotor and polyadenylation site usage) and post-transcriptional regulation (alternative splicing by inclusion or exclusion of exons) can also be informative of the role that specific disordered protein regions play in the cell.
Similar(42)
Intragenic DNA methylation is associated with regulation of alternative promoters, alternative splicing, and non-coding RNAs (ncRNAs) [ 38– 42].
Established modes of gene expression regulation encompass alternative transcription initiation, alternative mRNA splicing, posttranscriptional gene silencing and RNA editing.
Splicing mechanism is very carefully regulated as aberrant regulation of alternative splicing in human has been implicated in various diseases [ 30, 31].
We therefore postulate that the mechanism by which Eae23b regulates EAE is through regulation of alternative splicing of ZEB1 which in turn regulates IL2.
Currently, most studies concerning regulation of alternative splicing focus on a single alternative exon.
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