Sentence examples for regulating transposition from inspiring English sources
Studies of several transposable genetic elements have pinpointed the importance of the transpososome, a nucleoprotein complex involving the transposon ends and a transposon-encoded enzyme – the transposase – as a key in regulating transposition.
Therefore, it has been speculated that these antisense RNAs regulate transposition events by inhibiting expression of transposase mRNA [ 11].
This suggests an effective process for rapid evolutionary change and makes it clear why transposons and host genomes, although biological antinomies, have coevolved mechanisms that regulate transposition and mutational outcomes under environmental stress and optimize reciprocal survival in normal environmental conditions.
It was suggested that transposase binding at the secondary site may down-regulate transposition.
Thus, such spacers might be suggested to regulate IS transposition by targeting the mRNA of transposases, leading to the regulation of genome rearrangements.
In addition, some virulence genes are regulated by transposition [ 44] and it is proven that some insertions, deletions, inversions and chromosome fusions are caused by transposition [ 45, 46].
For example, spnIR has been reported to be localized in a mobile transposon and was found to regulate the transposition frequency [ 44].
Deleterious mutations fixed by genetic drift as a consequence of a reduction in the effect of natural selection can also inactivate host genes that negatively regulate IS element transposition activities (Roberts et al. 1985; Valle et al. 2007).
Indeed, a growing body of evidence suggests that LINE-1 transposition plays a critical role both in cell differentiation and in regulating the mammalian transcriptome (Coufal et al. 2009; Zemojtel et al. 2007).
Transposition is thus regulated during assembly of the transpososome, before productive synapsis of the ends.
