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In addition to SIX1 overexpression as we described above, the disabled homolog 2 (DAB2) – a recently characterized protein involved in mitogen response – might play a key role in regulating this switch in HNC [84].
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Blind males could perceive light that regulates this switch in various ways.
In search for the Notch-dependent effector regulating this cell fate switch, we found that Hes5, a Notch target and direct repressor of OLP specific genes, is regulated and mediates the activity of JAG2.
Among proteins regulating this type of switches is p53, which, depending on localization, can be involved in regulation of apoptosis, autophagy or necroptosis.
In this lecture I will illustrate how fibroblasts play an important role in regulating the switch from acute resolving to chronic persistent inflammation associated with the pathology of diseases such as rheumatoid arthritis [ 1].
In addition, proliferative cell types were predominant in the outer rim of the tumor confirming the role of microenvironment in regulating the switch.
Cyclic diguanylate (c-di-GMP) is a bacterial second messenger that activates biofilm formation while inhibiting motility, thus regulating the switch between a planktonic and a sessile lifestyle.
Mechanisms regulating the switch from latent to lytic infection may enable new strategies for treating EBV-associated cancers, referred to as oncolytic therapy.
What regulates the switch from closed to open conformation?
Different mechanisms are known to regulate the switch between autophagy and apoptosis.
Factors that regulate the switch from expression of OspA to OspC are likely varied and complex.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com