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These findings highlight a putative role of epigenetic regulation of Plasmodium zygotic development and add substantially to the emerging picture of the molecular mechanisms regulating this important stage of malaria transmission.
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Our findings indicate that CK2 regulates this important K+ channel under specific disease conditions.
To our knowledge, this is the first systematic target validation effort using the biological reporter system and thus, it is expected to provide more comprehensive view of how microRNAs regulate this important gene.
Although physical interaction with RiBi promoters has not been reported, overexpression of Sfp1 causes a rapid upregulation of most RiBi genes, suggesting that Sfp1 also regulates this important regulon (Jorgensen et al. 2004).
Such studies corroborate other studies indicating that a host's T cell response to HCV, including genes involved in regulating this response, is an important correlate of infection outcome.
Histone-based epigenetic mechanisms are important for regulating this undifferentiated state.
Previous studies using isolated chondrocytes proposed loading magnitude as an important factor regulating this response.
This suggests that polymer formation is important for regulating this enzyme in response to a build up of its product.
Some of the signaling molecules that are important in regulating this balance have been identified and are discussed below.
Notch and sonic hedgehog (Shh) signaling pathway have been shown to be important in regulating this transformation [ 14].
Phosphorylation of nucleoplasmin appears to be important in regulating this activity, as heavily phosphorylated nucleoplasmin is significantly more active [ 7].
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