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However, it does not explain the enhanced basal FPCL contraction rates of disease cell cultures, suggesting that other signalling factors may be regulating this disease cell function in vitro.
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Improved biomarkers will result from a better understanding of molecular mechanisms that regulate this disease.
Theoretically, if the inhibition of a certain gene can affect the pathogenesis and development of a disease, drugs regulating this gene might be effective for its treatment.
Furthermore, we have also uncovered novel microRNA-gene interactions that may regulate the disease progression from latent to active TB.
However, our understanding of the factors that regulate metastasis in this disease is limited.
Therefore, in one defined model system, tumor cell-autonomous and non-autonomous pathways regulating human disease progression can be investigated in a humanized, clinically relevant context.
This study emphasises the importance of acknowledging the role of the microenvironment in regulating MM disease when investigating new means of therapeutically targeting MM.
Cai et al. (2008) [ 26] found a Tubby-like gene in rice was involved in regulating a disease response gene.
However in a functional characterization study of the Eae18b congenic strain, Ccl11 was conclusively identified to be regulating many different disease pathways in this strain [ 30].
Using such an approach, it was found that one of the network hubs, daf-2, was connected to many of the up- and down-regulated genes directly, and then these genes were further connected to others, thus indicating the importance of the DAF-2 protein in regulating gene expression in this disease model.
Biologics are fundamentally nature's way of regulating disease, so we're manufacturing almost the perfect drug".
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