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Our finding proposes the notion that differential regulation of angiogenesis pathways may further be biologically relevant to the variant propensity of medullary versus extramedullary plasmacytomas to progress to MM, similar to their role in regulating the progression of MGUS to MM.
These data suggest that FZD7 knockdown suppressed cell proliferation by influencing cell cycle regulation without affecting apoptosis, indicating that FZD7 might have an important role in regulating the progression of the cell cycle in OC.
…mammalian target of rapamycin (mTOR), a kinase (an enzyme that adds phosphate groups to other molecules) that plays a fundamental role in regulating the progression of the cell cycle.
Thus, these studies establish a role for TBX5 in regulating the progression of the cardiac cell cycle.
MiR-21 has been demonstrated positively regulating the progression of DSS induced colitis and miR-21 deficient mice showed improved survival rate during DSS induction (Shi et al., 2013).
The mitotic checkpoint functions to ensure accurate chromosome segregation by regulating the progression from metaphase to anaphase.
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Cyclin D1, which complexes with cyclin-dependent kinase 4 (Cdk4) to regulate the progression from G1 to S phase [ 31, 32], was down-regulated early and repressed 1.7-fold to 48 hrs.
ERS regulates the progression of atherosclerosis together with several other factors, such as Nox4, TRPC3, SR-A1, and AMPK2.
Eukaryotic cells have to regulate the progression and integrity of DNA replication forks through concomitantly transcribed genes.
These findings suggest that simply modulating the matrix mechanical properties of a given wound dressing biomaterial deposited at the wound site could regulate the progression of wound healing.
We, therefore, propose that oxidation serves as a switch mechanism that down-regulates the progression of acute inflammation by sequestering TNF-alpha, IL-2, and IL-6, while up-regulating the development of tissue repair processes by releasing bFGF, beta-NGF, PDGF, and TGF-beta from binding to alpha2M.
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