The results presented here suggest that pathways regulating the function of apparently antagonistic epigenetic regulators converge to maintain ESC identity, notably in their ability to give rise to a well-balanced pattern of differentiation between the three germ lineages.
They play a major role in progression through the G1 restriction point [ 10, 12, 20] by regulating the function of pRb (retinoblastoma protein), which in its hypophosphorylated form (the functionally active form) can arrest cell cycle in G1 [ 12].
Allosteric regulation of ligand binding is a well-established mechanism regulating the function of G protein-coupled receptors (GPCR).
Arrestins play an important role in regulating the function of G protein-coupled receptors including receptor desensitization, internalization, down-regulation, and signaling via nonreceptor tyrosine kinases and mitogen-activated protein kinases.
Membrane proteins that respond to changes in transmembrane voltage are critical in regulating the function of living cells.
These two types of specific, acquired immunity, however, are not as distinct as might be inferred from this description, since T cells also play a major role in regulating the function of B cells.
Continued studies are necessary to further elucidate the immune defense mechanisms regulating the function of OECs and their interaction with S. pneumoniae, as they represent a potential line of defense against infectious pathogens in the OB.
Bacterial fermentation products, particularly short-chain fatty acids (SCFAs) including acetate (C2), propionate (C3), and butyrate (C4), mediate the effects on host physiology and immunity, regulating the function and differentiation of virtually all immune cell repertoire of gut4,5.
This study emphasizes that locally controlled levels of phosphoinositides are important for regulating the function of actin-binding proteins which effect changes in the membrane architecture.
To elucidate the role of RU486 in regulating the function of granulosa luteal cells and its possible involvement in ovarian dysfunction.
The most significant finding mapped to a micro-RNA, MIR-137, which may be involved in regulating the function of other schizophrenia and bipolar disorder susceptibility genes.
