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Our previous observations of Ser phosphorylation regulating subsequent ubiquitination left the relationship between these two modifications and the enzymes involved unknown [ 15].
This suggests that NEIL1 binding to BER associated proteins is important in driving and regulating subsequent repair steps and supports the cellular interactome theory, which proposes that coordinated interactions between repair proteins are essential for the proper removal of DNA lesions.
Using our two-dimensional HAP Fn platforms, further studies of the role of Fn conformation in regulating subsequent cellular behavior, such as cell adhesion and growth factors secretion, will provide important insights into a wide range of physiological and pathological processes involving HAP cell interactions.
Additional evidence suggests that not only tryptic peptides but cleaved amino acids may serve as systemic signals regulating subsequent processes.
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Upon activation, TLRs recruit adaptor proteins such as myeloid differentiating factor 88 (MyD88) and trigger downstream signalling proteins such as NF-κB to regulate subsequent inflammation responses.
We propose that RNA and peptide binding re-shapes the conformational energy landscape of 3C to regulate subsequent functions, including formation of complexes with other viral proteins.
Myc regulates subsequent events that induce genes involved in ribosomal biogenesis among other biosynthetic processes.
Furthermore, the infective environment in which DCs are conditioned can influence the way they control and regulate subsequent T cell response [ 44].
In some primate species, close calls appear to have a dual function: calls addressed at a broad class of targets serve to maintain group cohesion, whereas the same calls directed at a specific target serve to regulate subsequent social interactions.
Enhancement of the chondrogenic phenotype can be achieved by ectopic expression of transcription factors to regulate subsequent expression of their target genes which are often lost due to cellular dedifferentiation or in pathological conditions such as osteoarthritis.
The presence of a misformed vasculature in such mice suggests that Notch signalling does not function early in vasculogenesis, but rather regulates subsequent remodelling events that pattern the vascular network.
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CEO of Professional Science Editing for Scientists @ prosciediting.com