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MCPIP1 acts as an RNAse regulating stability of some mRNA coding for proinflammatory cytokines and also regulates activity of transcription factors, which are key regulators in carcinogenesis (e.g., NF- κB) [ 18– 218.
Sumoylation plays an important role in regulating stability and subcellular localization of targeted proteins [ 28, 29].
What are major factors for regulating stability of missense mutant pVHL is still under question.
Phosphorylation in the linker regions serves an important function in regulating stability, activity and transport of R-Smads.
Both BUBR1 and BUB1 are bifunctional proteins, being involved in the SAC as well as in regulating stability of kinetochore microtubule interactions (Bolanos-Garcia and Blundell 2011).
Recently, one study demonstrated that Rpd3 and Hda1 may partially compensate for each other in response to DNA damage by regulating stability of the endonuclease Sae2 (Robert et al., 2011).
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We do not find any evidence to support that αNAC regulates FADD by regulating protein stability because the depletion or overexpression of αNAC did not significantly change the FADD level.
It has been proposed that the majority of PPR proteins are targeted to plastid or mitochondria [ 34], and many genetic and biochemical studies conclude that PPRs directly bind to a specific RNA sequence and promote anterograde regulation such as post-transcriptional splicing, processing, editing or regulating mRNA stability [ 53- 60].
Ubiquitin-mediated modification plays a critical role in regulating protein stability (Ciechanover and Schwartz, 1994).
Ubiquitination is the process of ligating Ub molecule(s) to a substrate protein, in turn regulating protein stability and translocation.
This general strategy for regulating protein stability should enable conditional perturbation of specific proteins with unprecedented control in a variety of experimental settings.
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