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Htz1 has previously been implicated in regulating sense transcripts and we now show that it affects antisense transcripts in budding yeast.
The Arabidopsis genome contains a large number of gene pairs that encode sense and antisense transcripts with overlapping 3' regions, indicative for a potential role of natural antisense transcription in regulating sense gene expression or transcript processing.
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Although the ideal experimental design to prove the importance of APA in down-regulating sense gene's protein level was to completely disrupt the usage of distal pA site in RNASEH2C, it was technical challenging to delete all the cis-elements near the distal pA site completely.
In addition, studies have demonstrated that targeting an antisense transcript using a siRNA approach can alter the levels of the sense transcript, by either up-regulating sense transcription or down-regulating sense transcription [ 40, 43], so the results are not always as expected.
AMPK is a key regulator sensing cellular energy status and systemic energy balance [ 48] and mediates the effects of adipose tissue kinins including adiponectin and leptin in regulating body weight, glucose and lipid homeostasis [ 48].
The LuxT regulator protein is a potential drug target for regulating quorum sensing (QS) in Vibrio alginolyticus.
Hexaploid wheat may possess a mechanism for regulating and sensing the total level of transcripts in the cell which can be derived from the homoeologues.
Thus periventricular hypothalamic tanycytes, which contact the CSF (cerebrospinal fluid) and the neuronal soma, may metabolically couple neurons from the arcuate and the ventromedial nucleus, regulating glucose-sensing activities.
This system is self-regulating, in the sense that it automatically ensures that over any length of time a parent will put in more or less the same amount of time that he or she receives.
I think you'll find that healthier food is almost self-regulating in the sense that you don't have an insatiable desire to keep eating it the way you might with junk food.
Finally, a 'stability band' is clearly identified, and it is clear that the system is 'self-regulating' in the sense that an equilibrium between auto-flocculation and stabilisation of new particles leads to a latex with a surface coverage of 80 95% at high solid contents.
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