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This hypothesis is supported by the fact that WUS and KNOX, with homologues that were up-regulated in pedicel AZs, are the key genes regulating maintenance of undifferentiated meristem cells [ 81- 83].
These data suggest that Eed1 and Ume6 act in a pathway regulating maintenance of hyphal growth thereby repressing hyphal-to-yeast transition and permitting dissemination of C. albicans within epithelial tissues.
The separation of physiological consequences depending on developmental time of HFD-exposure thus suggests that the pathways regulating maintenance of body weight or ultimately glucose homeostasis, be it downstream of adiposity, develop at different times.
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It is therefore important to thoroughly evaluate the role of AChR activity as a mechanism for regulating formation, maintenance and development of the NMJ.
Cushing et al have recently shown that the delicate balance of interactions regulating cell surface maintenance and lysosomal degradation upon cycling is due to the relative affinity of the PDZ interactions [37].
Conceivably, OSNs may die because altered levels of proteins such as Kirrel-2 and Nrp1 interfere with the mechanisms regulating establishment and maintenance of glomeruli with axons of defined OR identities.
tph-1 and daf-7 have established functional connections to conserved pathways for regulating metabolism, cellular maintenance, reproduction and longevity, such as the insulin/IGF pathway (Liang et al., 2006; Shaw et al., 2007; Narasimhan et al., 2011).
In addition, HIF-1α regulates self-renewal of APL leukemic blasts, which is coherent with the role of HIF factors in regulating stem cell maintenance in other hematopoietic contexts (Takubo et al, 2010; Wang et al, 2011; Zhang et al, 2012; Rouault-Pierre et al, 2013).
In support of this, it was recently shown that IRAK−/− mice have higher Treg proportions compared to wild type mice, suggesting that IL-1 signaling could be negatively regulating Treg development or maintenance [36].
Current research suggests that one role of miR-21 in cancer is regulating DNA repair and maintenance in response to treatment, particularly nucleoside analogs.
Brain-derived neurotrophic factor (BDNF) is a member of the neurothophic factor family, which plays a key role in regulating survival, growth and maintenance of neurons [ 6].
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