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Insulin is also important in regulating lipids.
In addition, we and other researchers previously demonstrated that DGKβ regulates spine formation by regulating lipids, and DGKβ knockout (KO) mice show impaired memory [7], [8].
The well-known lipid regulators including PPARα, FXR, LXR, and PXR bound to almost 50% of RXRα-bound regions suggesting the extensive role of RXRα in regulating lipids.
Thiazolidinediones are specific anti-diabetic agents because they can modify genes regulating lipids and carbohydrates by activating peroxisome proliferator-activated receptors (PPARs) [ 17, 18].
Although PPARα, LXR, FXR, and PXR have extensive roles in regulating lipids, they also have specific roles in regulating different types of lipids.
This analysis indicates that metabolic pathways regulating fatty acid, phospholipid, and cholesterol biosynthesis were coordinately decreased after deletion of Stat3 in type II cells, supporting an important role of STAT3 in regulating lipids biosynthesis in the lung.
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Retinoic acid (RA) and bile acids share common roles in regulating lipid homeostasis and insulin sensitivity.
The LD is the central organelle regulating lipid homeostasis and disorders of LD-associated proteins induce metabolic diseases like NAFLD.
We designed experiments to determine the role of SAA in regulating lipid metabolism in HepG2 cells using microarray technology.
Fish oil (FO) and tetradecylthioacetic acid (TTA) — a synthetic modified fatty acid have beneficial effects in regulating lipid metabolism.
While enzymes regulating lipid synthesis are often expressed in low levels in most normal tissue (Clarke, 1993), they are overexpressed in multiple types of cancers.
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