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miRNAs are also important in reproduction and are involved in regulating functionality of the ovaries, e.g., in the maintenance and differentiation of germline stem cells (Park et al. 2007).
By similarity with GTPases, a dynamic organization of the nucleotide-binding pockets between ATPase protomers is proposed to regulate functionality.
Both NLS sequence motifs (NLS-2 and −3) contain tyrosine residues that are potential sites for phosphorylation, e.g. to regulate functionality of the NLS.
A mechanism to post-transcriptionally switch amino acids within a protein core could be used to regulate functionality of the protein without regulating transcription of the gene for the protein.
Biomimetic coatings with cell-adhesion-regulating functionalities are intensively researched today.
However, the role of Gadd45a in regulating the functionality of ATM−/− HSCs is unknown.
It is conceivable that mutations in proteins within pathways regulating ABCA1 functionality (such as LXRβ or ABCA12) are more important for the outcomes than polymorphism of ABCA1 itself.
This study suggests that NO reduces the survival of OA synoviocytes by regulating mitochondrial functionality, as well as the proteins controlling the cell cycle.
Also, chondrocytes are not the only joint cells affected in OA pathology and, a recent study has shown that SNP reduces the survival of OA synoviocytes by regulating mitochondrial functionality, as well as the proteins controlling the cell cycle [ 52].
The extended longevity of animals with reduced expression of genes directly or indirectly involved in regulating MRC functionality is associated with the induction of different stress responses and it is regulated among others by the p53 C. elegans homolog cep-1 (Torgovnick et al., 2010; Ventura et al., 2009).
Application of GrowMatch to eliminate and/or properly regulate these functionalities led to the identification of 30 growth medium-specific regulatory constraints.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com