Besides the novel role of PTP1B in antioxidant defense reported herein, this phosphatase regulates duration and/or intensity of survival signals emerging from the tyrosine kinase receptor family.
This hypothesis seems in line with recent observations suggesting that the posterior hypothalamus likely plays a part in terminating rather than triggering attacks, thereby regulating the duration of an attack, giving rise to the different TACs that are principally distinguished by attack duration [4, 22].
[Lightning Talk] Probabilistic Modeling of Drosophila Sleep Reveals Mechanisms Regulating Sleep Duration and Structure.
Conversely, another intriguing explanation could be that a shift in mechanisms regulating the duration of an attack could have been responsible for the change in the clinical picture.
All three are cAMP-specific phosphodiesterases that hydrolyze cAMP into the inactive substrate 5'-AMP and therefore have a role in regulating the duration and magnitude of cAMP second messenger activities [72] [74].
In the mammalian nervous system SLO channels have been identified as providing a calcium-dependent means of regulating the duration of excitatory synaptic events, at both pre and postsynaptic terminals [26].
Acute and progressive thrombosis models can be obtained by regulating the duration of irradiation and power intensity of the LED.
GIRK channels play an important role in maintaining resting membrane potential and regulating the duration of action potentials (Hille 1992).
The ubiquitin protein ligase activity of c-IAP1 is responsible for regulating the duration of TNF signaling in primary cells expressing TNFR2 [ 35]; however, the exact role of these factors in TNFR2-specific signalling remains undefined.
Nrarp−/− embryos exhibited increased cleaved NOTCH1 protein expression in presomitic mesoderm and somites (Fig. 6), supporting the model that the NRARP protein functions as part of a negative feedback loop regulating the duration of the Notch signal in the paraxial mesoderm.
Fuentealba LC, Eivers E, Ikeda A et al. Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal.
