48 In summary, these data expand the role for SOX9 in regulating components of the ECM and begin to provide insight into its regulation by signaling pathways linked to fibrosis and related pathologies in the liver and other sites, such as the skin, kidney, lung, and major blood vessels.
Both miR-146a and miR-155 have also been implicated in the development of rheumatoid arthritis, possibly by regulating components of the inflammatory response [16], [17].
Since B cell receptor signaling is involved in B cell development, activation and differentiation [25], oncogenic FLT3 might provides proliferative and survival signal for B cells by regulating components of B cell receptor signaling.
The present mRNA expression profiling analysis has revealed an important role for Fra-1 in regulating components of complex regulatory networks controlling the lung injury and fibrosis.
Recent work in both C. albicans and S. cerevisiae found evidence for Swe1-dependent phenotypes in endocytosis mutants; combining deletion of SWE1 with a sla1 or sla2 mutation led to an increase in multinucleated cells, indicative of a Swe1-dependent checkpoint acting on (and regulating?) components of the endocytic machinery (Gale et al. 2009).
For instance, murine herpesvirus infections have been shown to provide protection from infection with other pathogens in mice by up-regulating components of the immune system [ 23].
The UPR attempts to alleviate ER stress by (i) decreasing protein synthesis, (ii) increasing the size of the ER, (iii) increasing the synthesis of ER chaperones and (iv) up-regulating components of the ER-associated degradation pathway.
In principle, hyperarcs can connect an arbitrary number of start nodes (regulating components) with an arbitrary number of end notes (regulated components).
IAPs are a part of complex signaling network, regulating components responsible for a diverse array of migration phenotypes.
A direct measurement of ROS is challenging because of their short lifetime and immediate reaction with redox state regulating components.
