Sentence examples for regulating checkpoints from inspiring English sources

This is consistent with BRCA1 regulating checkpoints and cell proliferation.

However few studies assessed the expression of the principal cyclin regulating checkpoint exit, cyclin D1.

CDKs regulate checkpoints that integrate mitogenic and growth inhibitory signals, coordinating cell cycle transitions.

DOI: http://dx.doi.org/10.7554/eLife.09017.015 Our in-depth analysis of IL-12 regulated checkpoints during the early effector CD8+ T cell programming in response to T. gondii vaccination has provided several new insights.

As potent effector cells of the innate immune system that rely on germline encoded receptors for activation, NK cells must pass tightly regulated checkpoints to the formation of a mature immunological synapse and subsequent cytotoxicity.

Glucokinase (GK) is an enzyme that catalyzes the ATP-dependent phosphorylation of glucose to form glucose-6-phosphate, and it is a tightly regulated checkpoint in glucose homeostasis.

Here, we describe a new pathway that regulates checkpoint kinase 1 (CHK1) activity, a key element controlling both checkpoints and DNA repair.

Our data are consistent with a growing body of evidence that ARTEMIS regulates checkpoint responses, perhaps in multiple phases of the cell cycle [ 11- 14].

ATM/Tel1 and DNA-PKcs respond primarily to DSBs that are involved in the nonhomologous end-joining pathway of DSB repair, whereas ATR/Mec1, which shares with ATM substrates in the DSB response pathway, regulates checkpoint activation after different types of DNA damage such as UV radiations and stalled replication forks.

ROS have been demonstrated to modulate respiration in mammals by regulating several checkpoints energy pathways and mtDNA homeostasis.

DOI: 10.1038/sj/bjc/6600099 www.bjcancer.com © 2002 Cancer Research UK The cyclins and the cyclin-dependent kinases (cdks) are important proteins regulating the checkpoints of cell cycle progression (Hunter and Pines, 1994).