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HNF4A is a transcription factor regulating a network of genes controlling insulin secretion and glucose regulation.
The EWS/ETS fusion proteins appear (i) to act as abnormal transcription factors regulating a network of target genes (e.g., manic fringe, PDGF-C, TGF βII receptor) (Arvand and Denny, 2001) and (ii) to influence post-transcriptional gene processing by interacting with components of the cellular splicing machinery (e.g., TASR, SF1 and U1C) (Knoop and Baker, 2001).
Khalili et al (2012) reported that ectopic expression of BRAFV600E in human primary melanocytes induces IL-1 α and β as well as IL-8, which along with IL-6 constitute a cohort of target genes that can promote tumour growth by regulating a network of cytokines (Walker and Woolley, 1999; Lederle et al, 2011).
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Under normal conditions, the FOXC1 transcription factor regulates a network of genes that involve both survival genes and apoptotic genes.
These help to regulate a network of proteins called the extracellular matrix, which provides structural support for cells.
It will be interesting to investigate whether these genes regulate a network of commensal-related coding sequences.
Androgens regulate prostate gland growth and differentiation by binding to the androgen receptor (AR), which regulates a network of androgen responsive genes for example, PSA.
It has been previously established that PTF1A regulates a network of transcription factors controlling acinar-specific gene expression (Masui et al., 2008, 2010).
Moreover, O'Day and colleagues (O'Day & Lal, 2010) underlines how microRNAs altered in breast cancer regulate a network of interconnected molecules, where the central node is represented by Myc.
Perhaps BET bromodomain proteins regulate a network of proteins involved in proliferation and only by performing mathematical modeling can we discover their role in controlling the G1/S transition.
In the present study, gene function analysis showed that in TM 86 cells, DEX significantly regulated a network centered around the RNA binding protein S1 or RNPS1, whereas FA significantly modulated a GR-dependent network.
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