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As the recognition of target mRNAs mainly depends on the small seed region within the mature miRNA, a single miRNA potentially regulates up to several hundred mRNA targets, thus orchestrating a large variety of cellular processes (Lim et al., 2005; Stefani & Slack, 2008).
The vitamin D receptor (VDR) gene regulates up to 200 genes [ 9], and mediates most effects of vitamin D on gene expression via formation of a heterodimer with the retinoid x receptor, which binds to promoter regions of many target genes [ 9].
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BrMADS20 was alternatively up and down-regulated up to 12 h and afterwards it showed down-regulation from 24 h - 48 h.
miRNA is known to regulate up to several hundreds coding genes, thus the integrated analysis of miRNA and mRNA expression data is an important problem.
In the presence of metallic sodium as a reducing agent, the N-doping amount can be regulated up to 0.12 of N/C atomic ratio by simply altering the initial HCB and PCP ratios.
These results demonstrate that GATA4/6 transcription factors play essential roles in regulating UP expression in RA-stimulated ESCs.
Each miRNA can regulate up to hundreds of targets and miRNAs are predicted to regulate a third of protein coding genes [3].
Estimates indicate that miRNAs may regulate up to one-third of the mammalian genome, suggesting miRNAs have a central role in regulating gene expression [27].
There are currently over 850 human microRNAs (www.miRBase.org V12) and they are thought to regulate up to 30% of the human genome [26].
The data demonstrate that UVA+UVB-irradiated human DCs are enriched for several gene sets regulated (up- or down-) by UV irradiation in keratinocytes and fibroblasts (Table S2).
42% of benzoate-dependent genes are regulated up or down, respectively, at pH 6 versus pH 7; they are candidates for cytoplasmic pH response.
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