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During mitosis, Ndel1 also regulates the alignment and segregation of chromosomes.
Some studies show that NEK2A regulates the alignment of chromosomes to the spindle (chromosome congression) through phosphorylating SGO1 at Ser14 and Ser507 [ 43].
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Therefore, future studies should examine how Bach1 interacts with dynein to regulate the mitotic chromosome alignment.
Understanding the molecular mechanisms responsible for regulating the process of chromosomal alignment is important because failure to accurately segregate chromosomes results in chromosome non-disjunction and aneuploidy [1].
Taken together, these findings warrant further studies about the molecular mechanism underlying how Bach1 regulates chromosome alignment during mitosis.
We identify CRMP4 as a GSK3 substrate that regulates chromosomal alignment during mitosis.
Our finding that CRMP4 loss of function results in a delay in mitotic progression is consistent with our hypothesis that GSK3 regulates chromosomal alignment through CRMP4.
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