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Jasmonic acid (JA) regulates a broad range of plant defense and developmental responses.
FXR is the key factor that regulates a broad range of genes encoding BA enzymes and transporters in liver and ileum (Fig. 1).
The activated serine-threonine kinase AKT regulates a broad range of target proteins involved in a variety of downstream signaling pathways [15].
At the cellular level, Wnt/β-catenin signaling regulates a broad range of functions, including the self-renewal and differentiation of stem cells.
The transcription factor NF-κB regulates a broad range of biological processes including innate and adaptive immunity, cell growth, differentiation, apoptosis, and tumorigenesis [1].
However, auxin regulates a broad range of developmental and physiological processes, and auxin transport and signaling is correspondingly complex [ 98, 99].
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The pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are two members of the nuclear receptor superfamily that regulate a broad range of genes involved in drug metabolism and transport.
These enzymes regulate a broad range of cellular and systemic responses to hypoxia by catalysing the post-translational hydroxylation of specific residues in the alpha subunits of hypoxia inducible factor (HIF) transcriptional complexes.
Immunoglobulin-like transcript 1 (isT1/LIR-7/LILRA2/CD85h) is one of the activating receptors in the ILT family whose members have been reported to regulate a broad range of cells involved in the immune response.
Nuclear receptors (NR) are a superfamily of ligand-activated transcription factors that regulate a broad range of biological processes including development, growth and homeostasis.
Ubiquitination is a major player in regulating a broad range of cellular processes, including cell division, differentiation, signal transduction, protein trafficking, and quality control [24], [25].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com