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In model (2), a quantitative trait, X, is affected by a single signaling pathway consisting of 3 FGU levels - a single S element that regulates 2 T (T1 and T2) elements, each of which controls 3 downstream B elements which have phenotypic effects of 4 or 8 units on trait X.
All TLRs, except TLR3, signal through the myeloid differentiation primary response gene 88 (MyD88) adapter protein, resulting in the activation of NF-κB and the cytokine genes that it regulates (2).
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ATM, but not RNF168, regulates BARD1 HP1 interaction.
(D) WNT11 regulates MMP2 protein in media.
Fig. 4: METTL3 regulates JAK2 and SOCS3 expression via m6A methylation.
NRT1.1 regulates CIPK8 and CIPK23 at the transcript level.
EZH2 negatively regulates CBX6 expression in a PRC2-dependent manner.
NLRC3 negatively regulates TLR4-induced activation of the PI3K AKT mTOR pathway.
Depletion of EZH2 upregulates TBX3 which then down regulates TBX2.
The Erk2 MAPK regulates CD8 T cell proliferation and survival.
In the cytoplasm, BAP1 regulates Ca2+-signaling mediated cell death.
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