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Recent studies have suggested the involvement of two IdeR (Iron dependent Regulator) regulated transporter proteins Rv1348 and Rv1349, also known as IrtA and IrtB respectively, in carboxymycobactin mediated iron acquisition and survival of mycobacteria in mouse infection model [10], [11], [12].
Zinc regulated transporter.
Iron regulated transporter.
According to the Rice Annotation Project Database (RAP-DB, http://rapdb.dna.affrc.go.jp/index.html), one Fe regulated transporter gene, OsIRT1 (Os03g0667500) is localized within the q FETOX-3 region.
As introduced above, CNT1 is a highly regulated transporter protein.
In fact, mptABC was hypothesised to represent the iron regulated transporter IrtAB in MAP [ 40].
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On the other hand, Fe-deficiency can cause Zn-excess, as Fe regulated transporters such as OsIRT1 are suggested to transport Zn and Arabidopsis plants under Fe-deficiency accumulate excessive Zn [ 39, 79].
Differentially regulated transporters important for uptake or efflux of RITA might serve as predictive markers for RITA sensitivity.
The genes that are upregulated under Fe-deprived conditions included those that are responsible for acquisition of Fe, such as siderophores, biosynthesis gene clusters mbt1 and mbt2, and Fe regulated transporters of siderophores irtA, irtB, Rv2895c, and esx [ 28].
Overall, for more than 85% of the T-box regulated transporters the functional annotation (molecular function and/or biological role) could be improved as compared to the entries in the reference database of NCBI.
Interestingly, no significant change was observed for the nodes of the jejunum vs. ileum comparison indicating that relative to all genes being differently expressed between the jejunum and the ileum the number of differently regulated transporters was not significantly higher.
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