Sentence examples for regulated transgene expression from inspiring English sources
Our most active transcriptional regulator was controlled by the retinoid X-α/ecdysone receptor system and effectively regulated transgene expression in response to the insect hormone ponasterone A in a dose-dependent manner.
This binary lentivector system resulted in tightly regulated transgene expression, with low basal cell activation in the absence of mifepristone (MFP).
The system, termed pB-Tet-GOI (piggyBac-transposable tetracycline transactivator-mediated flexible expression of a genetic element of interest), incorporates the latest generation of tetracycline (Tet) transactivator and reverse Tet transactivator variants along with engineered mutants in order to provide regulated transgene expression upon addition or removal of doxycycline (dox).
A derivative of these cells, 293TETOFF, which constitutively expresses the tetracycline transactivator protein tTA, was used as the starting point for the work, with the aim of isolating cell lines exhibiting regulated transgene expression.
Regulated transgene expression, whereby a promoter is specifically activated in response to pathogen invasion or pest attack, has distinct advantages for genetic engineering disease/pest resistant traits in plants.
Their findings have implications for the manipulation of plant height and yield, and demonstrate the efficacy of regulated transgene expression for functional genomics.
Antiprogestin-inducible gene regulation systems have been used to regulate transgene expression in cultured cells, transgenic animals, and for in vivo gene transfer studies using viral- or plasmid-based vectors.
Brown BD, Gentner B, Cantore A, et al. Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state.
Brown BD, Gentner B, Cantore A, Colleoni S, Amendola M, Zingale A, et al. Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state.
Brown, B.D. et al. Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state.
The ability to regulate transgene expression will be essential for the safety and efficacy of many gene therapies.
