Exact(32)
Tsang, Zhu, and Oudenaarden [31] outlined two types of miRNA circuits, as shown in Figure 7. Type I circuits: miRNAs and their corresponding targets are regulated together, implying short-term modulation of protein translation and a regulation of homeostasis of gene function.
Genes in such a pathway may be regulated together.
The accB and accC genes are frequently located in a two-gene operon and regulated together to control biotin synthesis [42].
We posit that these circuits are involved in tissue specificity and maintenance of cell identity, and would be regulated together with transcription factors.
Type I circuits, in which the miRNA and its target are regulated together would allow for modulation of protein translation, maintenance of cellular homeostasis, or modulation of changes in local protein concentrations.
Accumulation of raffinose is in agreement with the earlier increase in the transcript encoding for galactinol synthase GolS3, which has been shown to be important in response to cold [51], and which our data shows is closely regulated together with the raffinose synthase SIP1 (Figure S2).
Similar(28)
This suggests that Gpr52 and Rabgap1l could be co-regulated together, possibly facilitated by their shared genomic locus, via possible feedback regulation by Htt.
Interestingly, Jeong et al. (2013) observed that in transgenic rice plants over-expressing OsNAC5 under the control of a root-specific promoter, LOC_Os07g01020 was up-regulated together with other genes implicated in root growth and development.
Over 60% of the edges were shared between the networks, suggesting that it is common to find the same pair of genes both up and down-regulated together.
Two genes may be up-regulated together under the control of one transcriptional factor, but in the absence of that factor they might be independently controlled; if that were true our expectation would link the genes only in the "up-together" (pp) network.
That is, genes up-regulated together produce proteins that interact with each other.
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