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Such reduction was enhanced in the lungs and similar in the spleen of MyD88−/− mice suggesting that secretion of IL-6 in response to MHV-68, especially in the lungs, could be regulated through other mechanisms than TLR2 alone.
In our study, hypermethylation of miR-9.2/9.3 did not correlate with expression of miR-9, thus indicating that miR-9 might be regulated through other mechanisms; for example, regulated by PROX1 (a homeobox transcription factor) as has recently been reported (Lu et al, 2012).
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This analysis showed that many of the miRNAs were regulated through each other either directly or indirectly, and were also regulated by several target genes.
We observed that many miRNAs are regulated through each other either directly or indirectly, and many are indirectly regulated by the same signaling molecules, for example, beta estradiol.
The term epigenetics in general refers to heritable pattern of gene expression that is mechanistically regulated through processes other than alteration in the primary DNA sequences [ 1, 2].
The CYP3A4 promoter may also be regulated through mechanisms other than PXR effects, including glucocorticoid-induced CYP3A4 gene expression, through the established PXR-dependent pathway and a PXR-independent pathway [ 99].
The downregulation of NDRG1 occurred in cells treated with either lovastatin lactone or lovastatin acid, indicating that its expression might be regulated through pathways other than the inhibition of pAkt.
Some auxin-regulated gene expression may be regulated through signalling pathways other than TIR1, and could involve AFB5.
Finally, the sumoylation system can also be regulated through crosstalk with other post-translational modifications, including phosphorylation, ubiquitination, and acetylation.
Perhaps similar to the soluble Fz-ICD [40], LRP6-ICD nuclear localization is regulated through interaction with other proteins in a context-dependent manner.
Estrogen-responsive genes without ER binding sites may be regulated through interaction with other transcription factors or via non-genomic actions.
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