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Abnormal formation of synapses and dendritic spines, for example, by modulation of the neurexin neuroligin cell-adhesion system, or by poorly regulated synthesis of synaptic proteins.
Later responses involve the transcriptionally regulated synthesis of E-selectin, vascular cell adhesion molecule 1 and intercellular adhesion molecules.
We and others have developed effective genetic stabilization systems for enhancing the retention of multicopy plasmids encoding regulated synthesis of foreign antigens, without the further requirement to select with antibiotics.
Although most synthesis of 1,25(occursoccurs in the kidney and is tightly homeostatically regulated, synthesis of 1,25(OH)2D can occur in a wide range of tissues, including the epithelial tissues of the colon.
These data are consistent with a model in which DNA replication is regulated within the cell cycle, in part, by the regulated synthesis and degradation of the replicative machinery [46].
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But live organisms have the endogenous ability to exquisitely regulate synthesis of inorganic materials.
Farnesoid X receptor (FXR) can regulate synthesis, metabolism, and excretion of bile acids.
We also show that TG2 regulates synthesis of the cartilaginous glycosaminoglycan (GAG -rich extracellular matrix.
ST35GAL5, which regulates synthesis of GM3, a prominent ganglioside in late lactation [38], had high expression in late lactation milk.
It is also possible that other systems involved in maintaining protein homeostasis modulate the network by regulating synthesis and degradation of some of these chaperones.
Only ST8SIA1, which regulates synthesis of GD3, the most abundant ganglioside in early lactation bovine and human milk [38], showed a higher expression in transition milk.
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