These results indicate that these two Rho-GEFs regulate sorting into secretory granules, constitutive-like secretion from ISGs, and perhaps constitutive secretion, and provide a novel mechanism for the regulation of secretory granule maturation.
Since Salmonella infection results in polyubiquitination of MHC-II, and ubiquitination regulates sorting of MHC-II at MVBs [ 10, 15], these results may suggest that Salmonella-induced ubiquitination of MHC-II enhances accumulation in MVBs to prevent recycling of mature MHC-II to the cell surface.
"It's not a kind of meticulous, measured and regulated sort of stroke," said Cooks, who plans to touch on jazz album cover art in her next book.
Rab7 is a marker for late endosomes and its activity regulates sorting of cargoes from early endosomes toward the late endosome/lysosome pathway [55].
In Xenopus, cadherins do not seem to be the only molecules at the cell cell contact regulating sorting of germ layer progenitors [60,101].
Because sortilin binds to the prodomains of both proNGF and proBDNF to regulate sorting of mature NGF and BDNF to appropriate endocytic and secretory pathways (Chen et al., 2005), transfected cells were also treated with proNGF, proBDNF, and with a combination of proNGF/proBNDF.
Lastly, our model explains the differences in sorting observed in actin filaments vs 2D networks, and the role of the myosin lever arm in regulating sorting.
Wang Y, Zhou Y, Szabo K, Haft CR, Trejo J. Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1.
The endosomal compartment required for CHIKV entry was investigated by mean of overexpression of dominant negative mutants of Rab-family GTPases that regulate transport, sorting and maintenance of endosomal vesicles along the endocytic pathway.
Anti-LBPA induced a marked distortion of GFP-RhoB-positive endosomes that appeared as dilated structures containing anti-LBPA (Fig. 3f), confirming that late endosome-specific lipids regulate RhoB sorting into MVB.
