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Synthesis of rRNA is a highly regulated response to the nutrients available to the cell (for review see [22]).
Single-cell variation in the timing of actively regulated response to cations could explain the cytosolic free calcium oscillations observed in E. coli [14] together with the increased variability observed with increased cation concentration (Fig. 6).
Both the longevity and increased autophagy of DR animals require the FOXA transcription factor PHA-4, suggesting that autophagy is a transcriptionally regulated response to DR [ 145, 148].
Finally, many genes with changed acetylation without detected p53 binding may also be secondary targets, downstream on the p53 regulated response pathway.
Changes in cellular oxygen concentrations induce tightly regulated response pathways that attempt to restore oxygen supply to cells and modulate cell function in hypoxic conditions.
Wound repair is a highly regulated response and aberrant wound healing and persistent presence and activation of fibroblasts can result in pathological scarring [ 8].
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The homologous gene in S. cerevisiae regulates response and resistance to low pH and acidic conditions (Mira et al. 2009).
Furthermore, putative mechanisms that regulate response to bisphosphonates in other tumour types remain to be evaluated in breast cancer.
Transcription factors predicted to regulate response.
This dichotomy of p53 pathway components regulating response to therapy was confirmed in vitro.
On the other hand, modulating duration on the sub-minute timescale does not regulate response dynamics.
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