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In addition, HSP-independent mechanism may be involved in HSF1 regulated resistance of cancer cells to chemotherapeutics.
Secondly, chemotherapy may induce novel genetic mutations in EGFR or other unknown associated genes that regulated resistance to TKI.
The steady increase of transcripts of PR-1 and stilbene synthase genes likely contributes to the developmentally regulated resistance during ripening of Norton berries.
The expression data support the view that constitutive expression of defense genes in the sweet cherry exocarp protects the developing fruit and contributes to developmentally regulated resistance to pathogens.
Previously, overexpression studies examining a pair of allelic genes OsWRKY45-1 and OsWRKY45-2 demonsthated thesethese genes positively regulated resistance to the rice fungal pathogen Magnaporthe grisea[ 28].
In summary, developmentally regulated resistance of Norton ripening berry to pathogens likely is a result of the steady increase of transcript abundance of R genes, PR-1, stilbene synthase genes, and genes of the phenylpropanoid pathway along the berry skin development.
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By regulating CCNB1, it may regulate resistance in gefitinib-resistant NSCLC cells.
A third example is Arabidopsis enhanced disease resistance 4 (EDR4) negatively regulating resistance to powdery mildew.
Rice MPK12 positively regulates resistance to Xoo (Seo et al. 2011).
Our study revealed that OsHsp18.0-CI positively regulates resistance to bacterial leaf streak in rice.
These results suggested that OsHsp18.0-CI positively regulates resistance to Xoc in rice.
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