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Also in cells that demonstrate a highly dynamic physiologically regulated range of secretory demand, like insulin secretion in pancreatic β-cells, the UPR is involved [ 91].
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Of these 450 E-dependent DEG, 291 were up regulated (within a range of 2 to 47-fold change), and 159 DEG were down regulated (range between −2 to −15.7-fold change) in the absence of E. We hypothesised that some of the E-dependent DEG would be involved in downstream molecular pathways important for maintaining the female gonad.
The BMW X5 was within the regulated range.
An average of 2206 features were up-regulated (range, 1091-3763) and 1986 down-regulated (range, 750-3058) between MKs and each other cell type.
Comparison of the SCZP-derived cells revealed 752 up-regulated (range from 0.56 to 3.4) and 818 down-regulated (ranging from −0.54 to −4.97) genes.
In addition, GSEA analysis highlighted that PVG cells up-regulated of a range of potassium channel genes (Table 4).
System A transporters are up-regulated in a range of human cancers, including breast cancer and hepatocellular cancer [ 6, 7].
In contrast, microarray studies have demonstrated that RASSF7 expression is up-regulated in a range of cancers [ 10– 14], but little is known about its function.
Spatiotemporally regulated silencing caused a range of malformed phenotypes that fell into three types: extra veins, thick veins, and depigmentation.
Another up-regulated gene, hsp-12.6, which encodes a small heat shock protein (sHSP) in C. elegans, is developmentally regulated but is not up-regulated by a wide range of stressors [ 47].
The miR-34 family of miRNAs is consistently down-regulated in a broad range of malignancies.
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