As novel gene biotechnologies, artificial genetic circuits that contain OR gate, AND gate, NOR gate and other genetic circuits are identified to not only regulate purpose gene expression but also control expression level of the downstream gene through optimal arrangement of elements.
Indeed, where we try to regulate general-purpose objects as though they were special and tricky, all kinds of bad, weird stuff happens, as with Britain's failing war on knives, which makes it a very tricky business for a young apprentice chef or model-maker to buy and transport the perfectly reasonable blade she legitimately needs, while still not making a dent in actual knife crime.
Over the years, the amount of water flowing over the falls was greatly reduced and regulated for the purpose of producing electricity, while unsightly outcroppings of rock were blasted away for scenic enhancement.
In higher eukaryotes, we typically think of such a gene as a solitary single-copy gene that is, for all practical purposes, independently regulated (i.e. gene regulation is not overwhelmed by regional effects).
In the UK the use of animals for research purposes is regulated by the Home Office and must comply with the Animals (Scientific Procedures) Act (Home Office, 2012) 1986 as amended in 2012.
In Israel, the law defines marijuana as an illegal and dangerous drug, and there is still no legislation regulating its use for medicinal purposes.
One thing is clear, they should not be regulated strictly for the purpose of protecting an established industry, which seems to be the case in Europe.
Over time, highly regulated "categorical" or specific-purpose programs proliferated.
For this purpose, differentially regulated genes were identified based on the infected:non-infected ratio, averaged over 2 biological replicates, for each time-point and for each tendency of regulation (Additional file 3).
We agree with Ms. Pauwels that any genetic database used for clinical purposes should be regulated.
