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The effects of temporally regulated presentation of pro-angiogenic and pro-maturation factors were investigated in vitro and in vivo in this study.
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Given the current findings, there is sufficient evidence to suggest that current regulation could be amended to more stringently regulate presentation of the advisory statement, maximising the opportunity for consumers to become aware of guidelines.
In vitro models suggest that induction of immunity is controlled by regulating the presentation of antigen, but little is known about how DCs control antigen presentation in vivo.
For each AKAP we have identified, possible mechanisms for regulating antigen presentation can be proposed.
A voluminous literature exists pertaining to the role of ROS in regulating antigen presentation.
HspBP1 deficient mice were used to verify the role of the co-chaperone in regulating antigen presentation on MHC class I molecules.
Thus it will be interesting to determine if anchoring of PKA to Ezrin might be regulating antigen presentation through integrin activation.
To determine if AKAPs have a function in regulating antigen presentation, we disrupted the PKA/AKAP interaction using the Ht31anchoring inhibitor and Ht31p control peptides.
Given their inhibitory role toward cathepsins, stefin proteins could regulate antigen presentation processes involved in immune response and autoimmune diseases [7], [8].
It also regulates antigen presentation by dendritic cells and shifts mature dendritic cells to immature precursor cells.
This finding raises the hypothesis that LPA can regulate antigen presentation by dendritic cells through the expression of CD1 molecules.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com