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Promoters PA0506 and PA2952 PA2951 were regulated negatively whereas promoters of PA2953 and PA3571 were regulated positively by PsrA.
For example, in E. coli the gene alaW is regulated (positively) only by fis.
Kinases can be constitutively active or be regulated positively or negatively by phosphorylation, which is ultimately kinase specific.
We identified ∼110 genes that were regulated positively more than 1.5 fold by FLCN knockdown and negatively by TFE3 knockdown (Table S2).
These indicate that p57 was the only cell cycle factor whose expression was confirmed to be regulated positively and negatively by the gain- and loss-of-functions of C/EBPβ, respectively.
We found that, consistent with the presence of sterol-responsive element consensus sequences in the promoter region of C11orf59, Pdro mRNA and protein expression levels are regulated positively by cellular cholesterol depletion and negatively by cellular cholesterol loading.
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This indicates genes prefer to regulate positively rather than negatively during the process of transcript regulation and post- transcriptional regulation.
The method provides the a posteriori probability that a given gene regulates positively, negatively or does not regulate each one of the network genes.
Together, these results suggest that CBF regulates positively proliferation, and negatively terminal differentiation, of skeletal myoblasts.
Phosphorylation of ASF1 by TLKs regulates positively dASF1 and hASF1a protein levels and hampers proteasome-dependent degradation of hASF1a.
Since Pnc1p regulates positively Sir2p in yeast [27], we wondered whether increased Pnc1p activity would result in increased Sir2p activity in CUG mistranslating cells.
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