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In contrast to the cell cycle regulated pattern observed for both BUBR1, BUB3.1 and MAD2 promoter, no GUS activity in dividing cells was observed for the BUB3.2 promoter in young leaves (Fig. 1A), lateral root primordia (Fig. 1B), lateral root meristems (Fig. 1C) and root meristems (Fig. 1D).
The laminin alpha-5 chain, however, is expressed by both epithelial and stromal cells in a developmentally regulated pattern.
2, 23 A similar, highly regulated pattern of development is recapitulated in many vertebrate species including mice, rats, and rabbits.
The endocrine cells in the pancreatic islets all arise from the same progenitor stem cell and the maturation of the different cell types is dependent on a number of factors, such as transcription factors and miRNAs, that are activated in a tightly regulated pattern [ 22, 23].
Such a regulated pattern of expression was also reported in bovine follicles [ 32].
Further studies revealed a specific and tightly regulated pattern of gene expression in developing rats, mice, and humans [ 8- 10].
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Users can select any growth condition, or up- or down-regulated pattern, and can input an integer that represents the number of most highly regulated genes to be shown.
Uromodulin-like genes were the predominant type showing an up-regulated pattern; uromodulin is also known to be highly expressed in the epidermis.
The simple GO enrichment results from 1,093 genes with the down-regulated pattern and 824 genes with the up-regulated pattern were used as input data.
The SST-regulated gene expression had two major patterns: (1) a temporally up-regulated pattern (463 genes) and (2) a temporally down-regulated pattern (177 genes).
Similar to photosynthesis, genes involved in glycolysis showed an up-regulated pattern.
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