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Regulated opening of Ca2+ channels within these membranes is the means by which most extracellular and intracellular signals evoke the increases in cytosolic Ca2+ concentration that regulate almost every aspect of cellular activity (1, 2).
Cytosolic Ca2+ signals regulate diverse cellular activities and most of these signals arise from regulated opening of Ca2+-permeable channels.
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We speculate that IRE1 α may regulate InsP3R-mediated Ca2+ release by interacting with ASK1 and calcium- and integrin-binding protein 1 (CIB1), the latter of which regulates opening of InsP3R.
We suggest that the PKA-ezrin-Cx43 macromolecular complex controlling the gap junction communication constitutes a general mechanism to regulate opening of Cx43 gap junctions by phosphorylation and in response to cAMP.
These residues are expected to be positioned near the 'shutter' region that regulates opening of β-sheet A during insertion, and are situated in close proximity to the C-terminal portion of the F-helix that has been found to undergo remodelling during polymerization [ 41].
In response to ischemia and Ca2+ overload, CypD-regulated opening of the MPTP leads to mitochondrial swelling (Halestrap, 2009).
This necessitates at least three servo valves which should be placed at the tip of the probe in order to regulate the opening of the orifices of each water-jet, thereby controlling the flow rate and thrust force.
He invented a system of diaphragms like those that regulate the opening of a camera shutter.
Rather than extend the dense pipelines of these tanks further into the growing city, this proposal regulates the opening of these sites to their surrounding urban fabric, so that they may become sites for public toilets as well as for the retrieval of potable water.
In order to make the ejector operate at critical or non-critical double-choking condition to obtain a better performance, an electronic expansion valve was installed in the suction line of the ejector to regulate the opening of the expansion valve to control the evaporator temperature.
Hiroshi Yamada, the youthful local mayor who has championed the new law, even reports a recent visit from the American government.Mr Yamada owes his moment in the spotlight to a new law regulating the opening of big shops in Japan, which took effect this month.
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