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FeP2 and PEPV regulated only one gene each involved in this response, Ctla2a and major histocompatibility (MHC) class I gene, H2-M2, respectively.
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In the 20 years since, the EPA has come close to successfully regulating only one new chemical contaminant in drinking water.
Undargaa argues that the crafting of institutions that regulate only one or two of these three production components has produced many of the unexpected and undesirable outcomes that the pastoral economy now experiences.
In all Cyanobacteria, the TPP riboswitch regulates only one gene per genome, thiC, which encodes an essential thiamin biosynthesis enzyme.
Master regulators (eQTLs regulating multiple genes) (Gilad et al. 2008) may be functionally more important and exhibit different evolutionary properties from those regulating only one gene.
Despite this coupling, signalling networks are often seen to allow one input to specifically regulate only one or a few outputs.
While many TF-encoding genes regulate only one adjacent target gene, others regulate many: the gene encoding TF FhlA, for example, regulates 14 collinear target genes adjacent on the E. coli K12 chromosome.
The E. coli TF with the largest number of 'outgoing regulatory connections' regulates 38 other TF genes, but is itself regulated by only one TF; the TF with the largest number of 'incoming regulatory connections' is regulated by nine other TFs but itself regulates only one TF gene.
We also checked that Fig. 2A does not change significantly if one limits the analysis to genes without diverging promoters ensuring that a given intergenic could possibly regulate only one gene.
For simplicity, we assumed that GA is homogeneously distributed in the modelled spatial domain and that the signalling pathway regulates only one of the network's components at a time.
Interestingly, among the functionally redundant DNA repair genes MutT and MutS, we found that RosR regulates only one of each of the paralogs (e.g. mutS1 and not mutS2/ 3).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com