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Importantly, the expression of genes downstream from oncogenes and suppressor genes are ultimately dependent on these regulated modifications of DNA and histones.
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Additional protein lipid, and lipid lipid interactions provide regulated modification of ER membrane phospholipid composition which are required to support the cooperative interactions required for selective transport.
PmrA/B control only a subset of the genes that regulate modifications of the LPS, and pmrA mutants remain resistant to some antimicrobial peptides such as cathelicidin.
This potential activity of Not4 toward mRNA processing and export factors may regulate modification of their function through mono-ubiquitination or target them for degradation through poly-ubiquitination.
The readout of the genetic information of eukaryotic organisms is significantly regulated by modifications of DNA and chromatin proteins.
In cyanobacteria, changes in the availability of carbon and nitrogen have also been linked to redox regulated posttranslational modifications of protein bound thiol groups.
The different cell fates can be regulated through modifications of tissue culture conditions and it has been reported that HSCs have an ability to induce osteoblast differentiation of multipotent mesenchymal stem cells, thus contributing to the creation of the stem cell niche [ 49].
FOXP3 is known to both activate and repress target genes by epigenetically regulating histone modifications of target promoters.
Recently snoRNAs are predicted to regulate posttranscriptional modifications of pre-mRNA.
These researchers insightfully argued that "the in vivo proteolytic activity and the in vivo substrate specificity of the proteasome may be regulated by modification of its subunit composition during fly development" (Haass and Kloetzel, 1989).
Carrot growth and development may be regulated by modification of the genes involved in gibberellin biosynthesis, catabolism, and perception.
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