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Regulated migration of T cells and DCs from the periphery to and within the lymphoid tissues is a key element in the induction of immune responses [31].
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In all cell line tested, Mitostatin over-expression inhibited the ability of cells to migrate (Figure 3A) indicating that Mitostatin negatively regulates migration of prostate cancer cells.
Bagri, A. et al. The chemokine SDF1 regulates migration of dentate granule cells.
Gong, J. et al. The SDF-1/CXCR4 axis regulates migration of transplanted bone marrow mesenchymal stem cells towards the pancreas in rats with acute pancreatitis.
This evidence demonstrates that Jak3 has a role in regulating migration of mBMDCs to the LN.
The distribution of CPA6 in the tail further illustrates non-myogenic localization and suggests a potential role in regulating migration of somitic precursors.
SDF-1α is a small secreted peptide belonging to the CXC family that regulates migration of leukocytes, especially during immune and inflammatory reactions [3], [4].
Chemokines are a large family of small structurally homologous cytokines that stimulate leukocyte movement and regulate migration of leukocytes from the blood to the tissue.
We have earlier demonstrated that S1P-induced activation of Rac1 regulates migration of HPAECs [12], and more recently identified a role for phospholipase D (PLD) dependent activation of IQGAP1 via Rac1 in hyperoxia-induced reactive oxygen species production in human lung endothelium [40].
CCHCR1 has also been proposed to regulate migration of the RNA polymerase II subunit 3 (RPB3) [32], that activates the activating transcription factor 4 (ATF4 or CREB2) [31] associating with growth arrest [34], [35] and being able to form heterodimers with members of the AP-1 family.
and regulates migration of the endothelial cell through the extracellular matrix during vessel formation [ 7, 8].
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