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One potential source of RRC is a regulated increase of substrate entry into the TCA cycle that is synchronized with an increase in the electron transport chain (ETC) activity.
Regarding the roles of PA in the abiotic stress response, it is suggested that PA produced by high PLDα1 activity destabilizes the membrane and increases membrane leakage, whereas a regulated increase of plasma membrane PA by PLDδ may produce signalling PA species that mitigate stress damage [ 63, 65].
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As another example, at puberty in girls, a carefully-regulated increase of estrogen and gonadotropin levels switch on the reproduction (program, function).
In the case of Lef1, our analysis revealed a developmentally regulated increase in the inclusion of exon 6, which encodes a part of the domain involved in protein protein interactions with different cofactors (Giese et al. 1995; Bruhn et al. 1997; Balmelle et al. 2004).
This report of a regulated increase in both expression as well as channel function supports our hypothesis that TREK-1 channels are important in maintaining quiescence during pregnancy and that channel expression and or activation may be dysregulated in spontaneous pre-term labor.
Moreover, the combined effects of modest and regulated increases in p53 and Ink4/Arf result in a significantly elongated lifespan and delayed organismal aging (Matheu et al., 2007, 2009).
The IMD-regulated increase in expression levels of the fly's presenilin representatives opens the opportunity to use the salivary glands for studying the physiological and pathophysiological role of these genes in a simple but functional environment.
This suggested that the RRC is a product of a co-regulated increase in the TCA cycle and electron transport chain (ETC) activities.
As petal senescence progresses, the number of down-regulated unigenes decreases, while that of up-regulated increases only at the stage D of visible symptoms of senescence (Table 1).
Our results showed that endothelial CD81 expression was gradually up-regulated with the increase of PMS concentration.
OBP Cmeg32081-c4 was highly expressed in the head of the female and Cmeg33593_c0 were up-regulated with the increase of larval age.
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