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These findings provide the significant cue to understand how a number of spliced genes are regulated in various tissue-specific manners by a limited number of regulators, eventually to understand developmental process or tissue-specific functions.
Our findings also provide the significant cue to understand how a number of spliced genes are regulated in various tissue-specific manners by a limited number of regulators, eventually to understand seemingly complicated developmental process or tissue-specific functions.
Except for ad hoc referendum calls by governmental authorities, procedures of direct democracy, particularly citizen-initiated procedures, are regulated in various aspects.
Ppar-γ expression is differentially regulated in various tissues with highest expression in adipose tissue and it regulates expression of many genes including CD36.
Alternative splicing is regulated by auxiliary cis-elements with regulatory proteins that enhance or repress splicing of adjacent exons [3], [4] however, the mechanism by which a number of genes are regulated in various tissue-specific manner by a limited number of regulatory factors remains unclear.
The glycerol metabolism is regulated in various ways.
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Although VEGF is known to be up-regulated in various tissues and cell types under hypoxia [ 3, 4, 13], the mechanisms that regulate sFlt-1 expression in microvessels under these conditions have not yet been fully clarified.
MicroRNA-21 (miR-21) is an oncogenic microRNA that regulates the expression of multiple cancer-related target genes, such as PTEN and PDCD4, and has been reported to be consistently up-regulated in various types of cancers, including colon, breast, lung, and stomach cancers [ 9- 16].
SIRT1, class III histone deacetylase, has been described to be up-regulated in various malignancies.
Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), two important enzymes in inflammatory responses are up-regulated in various tumor types.
Tarzarotene-induced gene 3 (TIG3) and HRAS-like suppressor (HRASLS3) are members of the HREV107 family of class II tumor suppressors, which are down-regulated in various cancer cells.
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