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It also provides broad and useful information to explore potential two-way level of gene expression control regulation in which microRNAs target multiple mRNAs, and, target mRNAs are regulated in parallel by multiple microRNAs.
SATB1 is a genome organizer protein that facilitates these processes, providing a nuclear architectural platform that anchors hundreds of genes, through its interaction with specific genomic sequences; this activity allows expression of all these genes to be regulated in parallel, and enables cells to thereby alter their function.
Here we report the existence of a set of known and unknown transcripts regulated in parallel with renin.
Amongst them were the complex I subunits Ndufb2 and Ndufs2, which were regulated in parallel with genes for synaptic function, signal transduction and ion channels [36].
Because DNA catenations persist without PIASγ in the absence of cohesin, removal of catenations and cohesin rings must be regulated in parallel.
We previously found that ERRα and ERRγ activate PPARA expression via direct binding to PPARA promoter B (−49,076 to −49,064 upstream of the translation start site) [28] and observed that myocardial ERRα transcript expression is developmentally regulated in parallel with PPARα [61].
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Any gene regulated in a parallel manner will allow better hypotheses as to the mechanism that is responsible for the time dependent effects.
Thus, these data show that two different transport systems of the blood brain barrier, one transporting primarily amino acids (LAT1) and the other primarily TH (MCT8 and OATP1c1), are regulated in a parallel manner in response to inflammation.
All genes are regulated in a parallel fashion except for caspase 1 with an opposite expression pattern of IL-6 (40-fold) as compared to NGF (-5-fold; Table 3).
Neutrophil CD64 expression is regulated in a graded fashion in parallel with the degree of inflammatory response to a significant clinical process of infection or tissue injury [ 10].
Whether Oct4 regulates pluripotency via adhesion or regulates both in parallel is difficult to resolve from our data set because the effective rescuers are transcription factors.
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