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"All the parts of ourselves that need to be contained or put in check or regulated in our day-to-day lives all fall by the wayside.
Genes involved in invasion, extracellular matrix remodeling, inflammation, and angiogenesis were differentially regulated in our 3D carcinoma model.
Given that, we wanted to know how p38MAPK is regulated in our model.
Notably, Bmp6 was strongly down regulated in our transgenic adenocarcinoma model.
On the other hand, several differentially expressed genes from Reymond et al. [22] were not significantly regulated in our experiments.
Thus, the question arises, whether we could not detect haptoglobin or ORM2 to be differentially regulated in our study.
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HDAC4, which encodes a histone deacetylase that represses transcription and regulates differentiation, was down-regulated in our experiments [ 43].
Several genes with a potential function in the regulation of the plant hormone homeostasis were up-regulated in our study.
Our results are consistent with these data, as this gene was also up-regulated in our leaf samples, both at 3 and 24 h of stress treatment.
Only atdmc1 was down-regulated in our microarray experiment (Table 3 and Figure 6C).
We also confirmed that ADAMTS5 is up-regulated in our C2C12 differentiation system using real-time PCR (Figure S1).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com