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There are two clusters that are enriched in immune response functions, and each is consistently regulated in mouse and macaque, but they show differential regulation in the Calu-3 cells.
Among 268 up-regulated genes, 16 genes are also shown to be differentially regulated in mouse uterus after estrogen treatment [47].
Although Wnt targets do not always have a MRE conserved between mouse and human orthologues (summarized in Supplementary Table 1), some targets previously found regulated in mouse progenitors (see Fig. 5) were also regulated in SUM159PT cells, including LEF1 and some FZD receptors.
Nevertheless, many established PPARα targets representing key genes in lipid metabolism are commonly regulated in mouse and human.
Pilot studies, in conjunction with published reports, confirmed that expression of all 12 genes is transcriptionally regulated in mouse macrophages in response to Mtb infection.
Most of the genes commonly regulated in mouse and human were involved in lipid metabolism and many represented known PPARα targets, including CPT1A, HMGCS2, FABP1, ACSL1, and ADFP.
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We determined that many of these miRNA transcription related targets are potentially directly involved in the expression of the 164 inflammation-related genes de-regulated in mouse scrapie; a gene interaction network to illustrate this is provided in Figure 6.
Tseng et al. found that C19orf80 is up-regulated in mouse liver by T3, a thyroid hormone that regulates liver lipid metabolism.
We could show that p63RhoGEF is up-regulated in mouse hearts subjected to transverse aortic constriction (TAC).
In addition, PTX3 was up-regulated in mouse mural GCs and cumulus-oocyte complexes (COCs) by TGF-β1 treatment, which was partially mediated by miR-224.
CLN3 is also up-regulated in mouse melanoma and breast carcinoma cancer cell lines.
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