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Further investigation of the specific p53 targets that are regulated in common across breast cancers and investigation of those that are differentially regulated across breast cancer subtypes will add to our understanding of the biology of breast cancer and breast cancer subtypes.
In such a comparison 114 genes were regulated in common (Figure 2).
Comparison of these data sets resulted in 2631 genes regulated in common in adenocarcinoma (data not shown).
Comparison of these data sets resulted in 2207 genes regulated in common in dysplasia (data not shown).
Further, in a comparison of the data sets of dysplasia vs transgenic and dysplasia vs non-transgenic 114 genes were regulated in common.
Using PAP we found that the 10 coexpressing genes of module 1 are regulated in common by the transcription factor MTF1 (found with p-value = 0.001).
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Furthermore co-expression analysis indicates that the lumen proteome encoding genes are transcriptionally regulated in a common manner, not only as a response to light, but uniformly across stress conditions, developmental stages and tissue types.
In turn, this led to the observation and enumeration of groups of proteins regulated in a common way, the so-called 'regulons'regulons
LIMS1 is activated by IL-6 as well as NGF and thus is one of few genes regulated in the common subset.
Also up regulated in this common data set are genes encoding small immune peptides such as Cecropins and Attacins as well as the gram-positive bacteria peptidoglycan receptor PGRP-SA (see Additional file 2).
Hildebrand asserted that canons should lead strictly regulated lives in common, imitating Christ's Apostles (vita apostolica), and renounce all personal property when admitted to a community of regular canons.
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